Deletions of the heavy neurofilament subunit tail in amyotrophic lateral sclerosis.

@article{AlChalabi1999DeletionsOT,
  title={Deletions of the heavy neurofilament subunit tail in amyotrophic lateral sclerosis.},
  author={Ammar Al-Chalabi and Peter Munch Andersen and Peter Nilsson and Barry A Chioza and Jesper L. R. Andersson and Carsten Russ and Christopher E. Shaw and John Francis Powell and Peter Nigel Leigh},
  journal={Human molecular genetics},
  year={1999},
  volume={8 2},
  pages={
          157-64
        }
}
Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron degeneration resulting in paralysis and death, usually within 3 years of onset. Pathological and animal studies implicate neurofilament involvement in ALS, but whether this is primary or secondary is not clear. The heavy neurofilament subunit (NFH) tail is composed of a repeating amino acid motif, usually X-lysine-serine-proline-Y-lysine (XKSPYK), where X is a single amino acid and Y is one to three amino acids. There are two… CONTINUE READING

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