Deletions of p15 and p16 in schistosomal bladder cancer correlate with transforming growth factor-alpha expression.

@article{Swellam2004DeletionsOP,
  title={Deletions of p15 and p16 in schistosomal bladder cancer correlate with transforming growth factor-alpha expression.},
  author={Menha Swellam and Abdullah Ahmed Abd El-Aal and Khadiga M AbuGabel},
  journal={Clinical biochemistry},
  year={2004},
  volume={37 12},
  pages={
          1098-104
        }
}
OBJECTIVES Cell proliferation is stimulated by growth factors and inhibited by p15 and p16 gene products. We compared cell regulators, TGF-alpha, p15, and p16, in schistosomal and non-schistosomal bladder cancer to explore possible differences in their alterations between the two subtypes and their correlations with proliferation pattern [synthetic phase fraction (SPF)], DNA ploidy, and clinicopathological factors. METHODS Tumor tissue samples were obtained from 120 patients. Expressions of… CONTINUE READING