Deletions of chromosome 8p and loss of sFRP1 expression are progression markers of papillary bladder cancer

@article{Sthr2004DeletionsOC,
  title={Deletions of chromosome 8p and loss of sFRP1 expression are progression markers of papillary bladder cancer},
  author={Robert Franz St{\"o}hr and Christoph Wissmann and Hiromu Suzuki and Ruth Knuechel and Ren{\'e} Christian Krieg and Eva Klopocki and Edgar Dahl and Peter Wild and Hagen J. Blaszyk and Guido Sauter and Ronald Simon and Ruediger Schmitt and Dirk Zaak and Ferdinand Hofstaedter and Andr{\'e} Rosenthal and Stephen B. Baylin and Christian Pilarsky and Arndt Hartmann},
  journal={Laboratory Investigation},
  year={2004},
  volume={84},
  pages={465-478}
}
Many molecular alterations are known to occur in urothelial carcinoma of the bladder, but their significance for tumor progression is poorly understood. Deletions of chromosome 8p are frequently found in several tumor types and are often associated with progressive disease. In all, 99 bladder tumors were screened for deletions at 8p using loss of heterozygosity (LOH) and multicolor fluorescence in situ hybridization FISH analyses. Allelic loss on chromosome 8p in at least one marker was found… CONTINUE READING

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