Deletions in Klebsiella pneumoniae R plasmids induced by growth in the presence of acridine orange at high temperature.

Abstract

The generation in vivo of plasmids deleted at specific sites in strains of Klebsiella pneumoniae containing R plasmids, by treatment with high concentrations of acridine orange (1.2 mg/ml) at 42 degrees C are reported. These deletions seem to be site specific because loss of specific restriction fragments after digestion with restriction enzymes was demonstrated.

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Cite this paper

@article{Zorzpulos1984DeletionsIK, title={Deletions in Klebsiella pneumoniae R plasmids induced by growth in the presence of acridine orange at high temperature.}, author={Jorge Zorz{\'o}pulos and A Trevisan and Claudio D. Denoya}, journal={Antimicrobial agents and chemotherapy}, year={1984}, volume={25 5}, pages={659-61} }