Deletions and duplications of the 15q11-q13 region in spermatozoa from Prader-Willi syndrome fathers.

@article{Molina2010DeletionsAD,
  title={Deletions and duplications of the 15q11-q13 region in spermatozoa from Prader-Willi syndrome fathers.},
  author={Oscar Molina and J. Blanco and Francesca Vidal},
  journal={Molecular human reproduction},
  year={2010},
  volume={16 5},
  pages={320-8}
}
Prader-Willi syndrome (PWS) is a genomic disorder mostly caused by deletions of 15q11-q13 region (70%). It has been suggested that the particular genomic architecture of 15q11-q13 region, characterized to be flanked by low copy repeats, could predispose it to Non-Allelic Homologous Recombination (NAHR). However, no studies in gametes of fathers of PWS individuals have been published to date. The objective of the study was to assess the incidence of 15q11-q13 deletions and duplications in… CONTINUE READING

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