Deletional self-tolerance to a melanocyte/melanoma antigen derived from tyrosinase is mediated by a radio-resistant cell in peripheral and mesenteric lymph nodes.

@article{Nichols2007DeletionalST,
  title={Deletional self-tolerance to a melanocyte/melanoma antigen derived from tyrosinase is mediated by a radio-resistant cell in peripheral and mesenteric lymph nodes.},
  author={Lisa A. Nichols and Yiming Chen and Teresa A. Colella and Clare Bennett and Bj{\"o}rn E Clausen and Victor H Engelhard},
  journal={Journal of immunology},
  year={2007},
  volume={179 2},
  pages={993-1003}
}
Self-tolerance to melanocyte differentiation Ags limits the ability to generate therapeutic antimelanoma responses. However, the mechanisms responsible for CD8 T cell tolerance to these Ags are unknown. We have used a newly generated TCR-transgenic mouse to establish the basis of tolerance to one such Ag from tyrosinase. Despite expression of tyrosinase transcripts in the thymus, central deletion does not shape the tyrosinase-specific CD8 T cell repertoire. We demonstrate that this endogenously… CONTINUE READING

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