Deletion variants within the NF-kappa B activation domain of the LMP1 oncogene prevail in acquired immunodeficiency syndrome-related large cell lymphomas and human immunodeficiency virus-negative atypical lymphoproliferations.
@article{Knecht1996DeletionVW, title={Deletion variants within the NF-kappa B activation domain of the LMP1 oncogene prevail in acquired immunodeficiency syndrome-related large cell lymphomas and human immunodeficiency virus-negative atypical lymphoproliferations.}, author={Hans Knecht and Martine Rapha{\"e}l and Cathy McQuain and Sylvia Rothenberger and German Albert Pihan and Sophie Camilleri‐Br{\"o}et and Edith Bachmann and G. R. Kershaw and Saleh Ryan and Ellen L. W. Kittler and Peter J. Quesenberry and Daniel Schlaifer and Bruce A. Woda and Pierre Brousset}, journal={Blood}, year={1996}, volume={87 3}, pages={ 876-81 } }
This sequencing study of 17 acquired immunodeficiency syndrome-related lymphomas (9 primary brain, 8 systemic) and 8 human immunodeficiency virus-negative atypical lymphoproliferations expressing large amounts of the latent membrane protein 1 (LMP1) of Epstein-Barr virus was performed to characterize the carboxy terminal NF-kappa B activation domain of LMP1 at the molecular level in an immunocompromised host. In-frame deletions within the NF-kappa B activation domain were identified in all but…
36 Citations
Deletion variants within the NF-kappaB activation domain of the LMP1 oncogene in acquired immunodeficiency syndrome-related large cell lymphomas, in prelymphomas and atypical lymphoproliferations.
- Biology, MedicineLeukemia & lymphoma
- 1997
The prevalence of the same mutational pattern in AIDS-related lymphoma as well as in hyperplastic reactive states and prelymphomas supports the hypothesis that these variants confer a growth advantage manifested under impaired cellular immunity.
High frequency of a 30‐bp deletion of Epstein–Barr virus latent membrane protein 1 gene in primary HIV non‐Hodgkin's brain lymphomas
- Biology, MedicineNeuropathology and applied neurobiology
- 2002
Its high incidence suggests that the oncogenic mechanism of LMP1 in the brain might differ significantly from that in systemic lymphoid proliferations, and might be enhanced by HIV infection.
The 30-bp deletion variant of Epstein-Barr virus-encoded latent membrane protein-1 prevails in acute infectious mononucleosis.
- MedicineThe Journal of infectious diseases
- 1997
A hypervariable region within the C-terminus of LMP-1 is identified, in a domain required for maximal stimulation of NF-kappaB activity, that is identical to those observed in Epstein-Barr virus-associated AIDS-related lymphoma.
Mutations in the Epstein-Barr virus latent membrane protein-I (BNLF-
- Biology, Medicine
Genetic changes described previously in the C-terminus of the LMP-1 gene in various malignancy derivedEBV strains are also presetit frequently in wild type viruses and do not simply define tumour specific EBV strains, which may play a role in EBV oncogenesis.
Selective outgrowth of a posttransplant B-immunoblastic lymphoma expressing a latent membrane protein-1 deletion variant.
- Medicine, BiologyTransplantation
- 1997
A B-immunoblastic lymphoma that developed in a pretransplantation EBV-seronegative woman 4 months after kidney transplant from her HLA-haploidentical brother is reported and has been in remission for 36 months.
Carboxy‐terminal sequence variation of LMP1 gene in Epstein–Barr‐virus‐associated mononucleosis and tumors from Serbian patients
- Medicine, BiologyJournal of medical virology
- 2012
This study demonstrated noticeable geographical‐associated characteristics in the LMP1 C terminus of investigated isolates of patients with mononucleosis syndrome, renal transplantation, and tumors, mostly nasopharyngeal carcinoma.
Deletion of Epstein-Barr virus latent membrane protein 1 gene in United States and Brazilian Hodgkin's disease and reactive lymphoid tissue: high frequency of a 30-bp deletion.
- Biology, MedicineHuman pathology
- 1997
Ethnic differences in the expression of Epstein-Barr virus latent membrane protein-1 mutations in nasopharyngeal carcinoma.
- BiologyMutation research
- 2000
MOLECULAR PATHOGENESIS OF EPSTEIN-BARR VIRUS ASSOCIATED POSTTRANSPLANT LYMPHOMAS: NEW INSIGHTS THROUGH LATENT MEMBRANE PROTEIN 1 FINGERPRINTING1
- Medicine, BiologyTransplantation
- 2001
The results show that highly selected CD34+ PBSCT does not protect against transfer of EBV positive founder cells of donor type PTL and that, after allo-SCT, recipient types PTLs are not uncommon and may be favoured by LMP1 deletion variant strains present in recipient lymphocytes.
Mutations in the Epstein-Barr virus latent membrane protein-1 (BNLF-1) gene in spontaneous lymphoblastoid cell lines: effect on in vitro transformation associated parameters and tumorigenicity in SCID and nude mice
- Biology, MedicineClinical molecular pathology
- 1996
Genetic changes described previously in the C-terminus of the LMP-1 gene in various malignancy derivedEBV strains are also present frequently in wild type viruses and do not simply define tumour specific EBV strains, and may play a role in EBV oncogenesis.
References
SHOWING 1-10 OF 34 REFERENCES
A deletion mutant of the LMP1 oncogene of Epstein-Barr virus is associated with evolution of angioimmunoblastic lymphadenopathy into B immunoblastic lymphoma.
- Biology, MedicineLeukemia
- 1995
Two patients with AILD that subsequently progressed into immunoblastic lymphoma (IBL) were studied to investigate whether the LMP1 deletion mutant was implicated in progression of AILD into IBL, and identical deletions and point mutations were revealed.
High expression of latent membrane protein 1 of Epstein-Barr virus and BCL-2 oncoprotein in acquired immunodeficiency syndrome-related primary brain lymphomas.
- Medicine, BiologyBlood
- 1995
The results indicate that the role of EBV genes and BCL-2 expression in lymphomatous cells differ as a function of their localization, and in AIDS-related primary brain lymphomas, this correlation between LMP1 and Bcl-2 overexpression may have a major implication in lymphmagenesis.
Mutational hot spots within the carboxy terminal region of the LMP1 oncogene of Epstein-Barr virus are frequent in lymphoproliferative disorders.
- Biology, MedicineOncogene
- 1995
A high frequency of non-random point mutations at preferential sites within the 3' (carboxy terminal) region of the LMP1 oncogene is revealed, suggesting that they are involved in EBV related lymphomagenesis and that they define a clinically relevant EBV strain.
Identification of potential hot spots in the carboxy-terminal part of the Epstein-Barr virus (EBV) BNLF-1 gene in both malignant and benign EBV-associated diseases: high frequency of a 30-bp deletion in Malaysian and Danish peripheral T-cell lymphomas.
- BiologyBlood
- 1994
The findings suggest that the 30-bp deletion and the 7 single-base mutations in the C-terminal part of the CAO-BNLF-1 gene do not characterize a new EBV type A substrain, but some of the positions of single base mutations are hot spots that may have mutated independently through the evolution of EBV strains.
Deletions within the LMP1 oncogene of Epstein-Barr virus are clustered in Hodgkin's disease and identical to those observed in nasopharyngeal carcinoma.
- Medicine, BiologyBlood
- 1993
It is suggested that partial deletions of the LMP1 oncogene occur at a particular localization and confer a proliferative phenotype to lymphoid cells in HD.
LMP-1 activates NF-kappa B by targeting the inhibitory molecule I kappa B alpha
- BiologyJournal of virology
- 1995
Results indicate that LMP-1 activates NF-kappa B in B-cell lines by targeting I kappa B alpha, a transcription factor controlling the expression of genes involved in cell activation and growth control, has been shown to be activated by L MP-1.
Expression of the BNLF-1 oncogene of Epstein-Barr virus in the skin of transgenic mice induces hyperplasia and aberrant expression of keratin 6
- Biology, MedicineCell
- 1990
The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family
- BiologyCell
- 1995
Epstein-Barr virus burden in Hodgkin's disease is related to latent membrane protein gene expression but not to active viral replication.
- BiologyBlood
- 1992
Viral burden in Hodgkin's disease is not primarily related to active viral replication, but is associated with LMP gene expression, as shown in cases containing many copies of viral DNA and of mixed cellularity histological subtype.