Deletion variants within the NF-kappa B activation domain of the LMP1 oncogene prevail in acquired immunodeficiency syndrome-related large cell lymphomas and human immunodeficiency virus-negative atypical lymphoproliferations.

@article{Knecht1996DeletionVW,
  title={Deletion variants within the NF-kappa B activation domain of the LMP1 oncogene prevail in acquired immunodeficiency syndrome-related large cell lymphomas and human immunodeficiency virus-negative atypical lymphoproliferations.},
  author={Hans Knecht and Martine Rapha{\"e}l and Cathy McQuain and Sylvia Rothenberger and German Albert Pihan and Sophie Camilleri‐Bro{\"e}t and Edith Bachmann and G. R. Kershaw and Saleh Ryan and Ellen L. W. Kittler and Peter J Quesenberry and Daniel Schlaifer and Bruce A. Woda and Pierre Brousset},
  journal={Blood},
  year={1996},
  volume={87 3},
  pages={
          876-81
        }
}
This sequencing study of 17 acquired immunodeficiency syndrome-related lymphomas (9 primary brain, 8 systemic) and 8 human immunodeficiency virus-negative atypical lymphoproliferations expressing large amounts of the latent membrane protein 1 (LMP1) of Epstein-Barr virus was performed to characterize the carboxy terminal NF-kappa B activation domain of LMP1 at the molecular level in an immunocompromised host. In-frame deletions within the NF-kappa B activation domain were identified in all but… Expand
Deletion variants within the NF-kappaB activation domain of the LMP1 oncogene in acquired immunodeficiency syndrome-related large cell lymphomas, in prelymphomas and atypical lymphoproliferations.
TLDR
The prevalence of the same mutational pattern in AIDS-related lymphoma as well as in hyperplastic reactive states and prelymphomas supports the hypothesis that these variants confer a growth advantage manifested under impaired cellular immunity. Expand
High frequency of a 30‐bp deletion of Epstein–Barr virus latent membrane protein 1 gene in primary HIV non‐Hodgkin's brain lymphomas
TLDR
Its high incidence suggests that the oncogenic mechanism of LMP1 in the brain might differ significantly from that in systemic lymphoid proliferations, and might be enhanced by HIV infection. Expand
The 30-bp deletion variant of Epstein-Barr virus-encoded latent membrane protein-1 prevails in acute infectious mononucleosis.
TLDR
A hypervariable region within the C-terminus of LMP-1 is identified, in a domain required for maximal stimulation of NF-kappaB activity, that is identical to those observed in Epstein-Barr virus-associated AIDS-related lymphoma. Expand
Mutations in the Epstein-Barr virus latent membrane protein-I (BNLF-
Aims-(1) To study the frequency ofputative malignancy associated point mutations and a 30 base pair (bp) deletion in exon 3 of the C-terminus of the EpsteinBarr virus (EBV) encoded latent membraneExpand
Selective outgrowth of a posttransplant B-immunoblastic lymphoma expressing a latent membrane protein-1 deletion variant.
TLDR
A B-immunoblastic lymphoma that developed in a pretransplantation EBV-seronegative woman 4 months after kidney transplant from her HLA-haploidentical brother is reported and has been in remission for 36 months. Expand
Carboxy‐terminal sequence variation of LMP1 gene in Epstein–Barr‐virus‐associated mononucleosis and tumors from Serbian patients
TLDR
This study demonstrated noticeable geographical‐associated characteristics in the LMP1 C terminus of investigated isolates of patients with mononucleosis syndrome, renal transplantation, and tumors, mostly nasopharyngeal carcinoma. Expand
Deletion of Epstein-Barr virus latent membrane protein 1 gene in United States and Brazilian Hodgkin's disease and reactive lymphoid tissue: high frequency of a 30-bp deletion.
TLDR
The unexpected finding of high incidence of 30-bp deletion in LMP1 gene in reactive lymphoid tissue and HD without EBV-positive Reed-Sternberg cells suggests that this deletion may not be relevant to HD pathogenesis in most cases. Expand
Ethnic differences in the expression of Epstein-Barr virus latent membrane protein-1 mutations in nasopharyngeal carcinoma.
TLDR
The results suggest that EBV-associated NPC-DNA mutations in LMP1 do not occur at equal rates in different racial groups and are more common at distinct sites in NPC tissue from Chinese and Inuit sources. Expand
MOLECULAR PATHOGENESIS OF EPSTEIN-BARR VIRUS ASSOCIATED POSTTRANSPLANT LYMPHOMAS: NEW INSIGHTS THROUGH LATENT MEMBRANE PROTEIN 1 FINGERPRINTING1
TLDR
The results show that highly selected CD34+ PBSCT does not protect against transfer of EBV positive founder cells of donor type PTL and that, after allo-SCT, recipient types PTLs are not uncommon and may be favoured by LMP1 deletion variant strains present in recipient lymphocytes. Expand
Mutations in the Epstein-Barr virus latent membrane protein-1 (BNLF-1) gene in spontaneous lymphoblastoid cell lines: effect on in vitro transformation associated parameters and tumorigenicity in SCID and nude mice
TLDR
Genetic changes described previously in the C-terminus of the LMP-1 gene in various malignancy derivedEBV strains are also present frequently in wild type viruses and do not simply define tumour specific EBV strains, and may play a role in EBV oncogenesis. Expand
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References

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A deletion mutant of the LMP1 oncogene of Epstein-Barr virus is associated with evolution of angioimmunoblastic lymphadenopathy into B immunoblastic lymphoma.
TLDR
Two patients with AILD that subsequently progressed into immunoblastic lymphoma (IBL) were studied to investigate whether the LMP1 deletion mutant was implicated in progression of AILD into IBL, and identical deletions and point mutations were revealed. Expand
High expression of latent membrane protein 1 of Epstein-Barr virus and BCL-2 oncoprotein in acquired immunodeficiency syndrome-related primary brain lymphomas.
TLDR
The results indicate that the role of EBV genes and BCL-2 expression in lymphomatous cells differ as a function of their localization, and in AIDS-related primary brain lymphomas, this correlation between LMP1 and Bcl-2 overexpression may have a major implication in lymphmagenesis. Expand
Mutational hot spots within the carboxy terminal region of the LMP1 oncogene of Epstein-Barr virus are frequent in lymphoproliferative disorders.
TLDR
A high frequency of non-random point mutations at preferential sites within the 3' (carboxy terminal) region of the LMP1 oncogene is revealed, suggesting that they are involved in EBV related lymphomagenesis and that they define a clinically relevant EBV strain. Expand
The Epstein-Barr virus latent membrane protein-1 (LMP1) mediates activation of NF-kappa B and cell surface phenotype via two effector regions in its carboxy-terminal cytoplasmic domain.
TLDR
Analysis of several LMP1 mutants in various human cell types indicated that many mutations that were functional in human cells were poorly tolerated in the rodent cells; a result that is in broad agreement with published Rat-1 transformation data. Expand
Molecular analysis of the LMP (latent membrane protein) oncogene in Hodgkin's disease.
TLDR
Conservation of oncogenic LMP regions coding for the protein domains known to be associated with transforming capacities and immunogenic functions are suggested and a considerable genomic heterogeneity of the coding region for the intracytoplasmic domain and the 3' untranslated mRNA region is found. Expand
Identification of potential hot spots in the carboxy-terminal part of the Epstein-Barr virus (EBV) BNLF-1 gene in both malignant and benign EBV-associated diseases: high frequency of a 30-bp deletion in Malaysian and Danish peripheral T-cell lymphomas.
TLDR
The findings suggest that the 30-bp deletion and the 7 single-base mutations in the C-terminal part of the CAO-BNLF-1 gene do not characterize a new EBV type A substrain, but some of the positions of single base mutations are hot spots that may have mutated independently through the evolution of EBV strains. Expand
Human immunodeficiency virus-associated systemic lymphomas may be subdivided into two main groups according to Epstein-Barr viral latent gene expression.
TLDR
Differences in EBV association and LMP-1 expression were found between a major group of HIV-associated systemic NHL with blastic cell morphology, including SNCC lymphoma and its variants, and anaplastic cell lymphomas. Expand
Expression of Epstein-Barr virus latent gene products in tumour cells of Hodgkin's disease
TLDR
The findings suggest that EBV is associated with more cases of HD than was previously recognised, that in positive cases RS cells express a latent infection protein phenotype which differs from that of other EBV-associated lymphomas, and that LMP expression is related to histologically aggressive subtypes of HD. Expand
Deletions within the LMP1 oncogene of Epstein-Barr virus are clustered in Hodgkin's disease and identical to those observed in nasopharyngeal carcinoma.
TLDR
It is suggested that partial deletions of the LMP1 oncogene occur at a particular localization and confer a proliferative phenotype to lymphoid cells in HD. Expand
LMP-1 activates NF-kappa B by targeting the inhibitory molecule I kappa B alpha
TLDR
Results indicate that LMP-1 activates NF-kappa B in B-cell lines by targeting I kappa B alpha, a transcription factor controlling the expression of genes involved in cell activation and growth control, has been shown to be activated by L MP-1. Expand
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