Deletion or activation of the aryl hydrocarbon receptor alters adult hippocampal neurogenesis and contextual fear memory.

@article{Latchney2013DeletionOA,
  title={Deletion or activation of the aryl hydrocarbon receptor alters adult hippocampal neurogenesis and contextual fear memory.},
  author={Sarah E Latchney and Amy M. Hein and M Kerry O'Banion and Emanuel Dicicco-Bloom and Lisa A. Opanashuk},
  journal={Journal of neurochemistry},
  year={2013},
  volume={125 3},
  pages={
          430-45
        }
}
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the toxicity of dioxin and serves multiple developmental roles. In the adult brain, while we now localize AhR mRNA to nestin-expressing neural progenitor cells in the dentate gyrus (DG) of the hippocampus, its function is unknown. This study tested the hypothesis that AhR participates in hippocampal neurogenesis and associated functions. AhR deletion and activation by the potent environmental toxicant… CONTINUE READING

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