Deletion of voltage-gated channel affects glomerular refinement and odorant receptor expression in the mouse olfactory system.

@article{Biju2008DeletionOV,
  title={Deletion of voltage-gated channel affects glomerular refinement and odorant receptor expression in the mouse olfactory system.},
  author={K. C. Biju and David Ronald Marks and Thomas Gerald Mast and Debra Ann Fadool},
  journal={The Journal of comparative neurology},
  year={2008},
  volume={506 2},
  pages={161-79}
}
Olfactory sensory neurons (OSNs) expressing a specific odorant receptor (OR) gene send axonal projections to specific glomeruli, creating a stereotypic olfactory sensory map. Odorant receptor sequence, G-protein cAMP signaling, and axon guidance molecules have been shown to direct axons of OSNs toward central targets in the olfactory bulb (OB). Although the OR sequence may act as one determinant, our objective was to elucidate the extent by which voltage-dependent activity of postsynaptic… CONTINUE READING