Deletion of tyrosine hydroxylase gene reveals functional interdependence of adrenocortical and chromaffin cell system in vivo.

Abstract

Catecholamines are produced in the medulla of the adrenal gland and may participate in the intraglandular regulation of its cortex. We analyzed the adrenal structure and function of albino tyrosine hydroxylase-null (TH-null) mice that are deficient in adrenal catecholamine production. Adrenal catecholamines were markedly reduced, and catecholamine… (More)

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@article{Bornstein2000DeletionOT, title={Deletion of tyrosine hydroxylase gene reveals functional interdependence of adrenocortical and chromaffin cell system in vivo.}, author={Stephen Bornstein and He Tian and Ali Al Haidan and Antje Boettner and Naoki Hiroi and Grame Eisenhofer and S M Mccann and Georgia Chrousos and Suzanne K Roffler-Tarlov}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2000}, volume={97 26}, pages={14742-7} }