Deletion of the virion host shutoff protein (vhs) from herpes simplex virus (HSV) relieves the viral block to dendritic cell activation: potential of vhs- HSV vectors for dendritic cell-mediated immunotherapy.

@article{Samady2003DeletionOT,
  title={Deletion of the virion host shutoff protein (vhs) from herpes simplex virus (HSV) relieves the viral block to dendritic cell activation: potential of vhs- HSV vectors for dendritic cell-mediated immunotherapy.},
  author={Laila Samady and Emanuela Costigliola and Luci P Maccormac and Yvonne McGrath and Steve Cleverley and Caroline E. Lilley and Jill Stader Smith and D. S. Latchman and Benny M. Chain and Robert S. Coffin},
  journal={Journal of virology},
  year={2003},
  volume={77 6},
  pages={3768-76}
}
Herpes simplex virus (HSV) infects dendritic cells (DC) efficiently but with minimal replication. HSV, therefore, appears to have evolved the ability to enter DC even though they are nonpermissive for virus growth. This provides a potential utility for HSV in delivering genes to DC for vaccination purposes and also suggests that the life cycle of HSV usually includes the infection of DC. However, DC infected with HSV usually lose the ability to become activated following infection (M. Salio, M… CONTINUE READING