Deletion of the vaccinia virus growth factor gene reduces virus virulence.

  title={Deletion of the vaccinia virus growth factor gene reduces virus virulence.},
  author={R. Mark L. Buller and Sekhar K. Chakrabarti and Jonathan A Cooper and Daniel R. Twardzik and Bernard Moss},
  journal={Journal of virology},
  volume={62 3},
The vaccinia virus growth factor (VGF) gene encodes a polypeptide with amino acid sequence homology to epidermal growth factor (EGF) and transforming growth factor alpha and is present twice, once at each end of the virus genome within the inverted terminal repetition. Recombination procedures were used to replace more than half of both VGF genes with a beta-galactosidase cassette which served as a color indicator for isolating an unconditionally viable VGF- mutant. The VGF- mutant genotype and… CONTINUE READING
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