Deletion of the serotonin 2c receptor from transgenic mice overexpressing leptin does not affect their lipodystrophy but exacerbates their diet-induced obesity.

@article{Wang2006DeletionOT,
  title={Deletion of the serotonin 2c receptor from transgenic mice overexpressing leptin does not affect their lipodystrophy but exacerbates their diet-induced obesity.},
  author={Biao Wang and F. Chehab},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={351 2},
  pages={
          418-23
        }
}
  • Biao Wang, F. Chehab
  • Published 2006
  • Biology, Medicine
  • Biochemical and biophysical research communications
The binding of leptin to hypothalamic neurons elicits inhibition of orexigenic NPY/AgRP neurons and stimulation of anorexigenic POMC/CART neurons. Projections of serotonergic neurons onto POMC neurons suggest that leptin and serotonin converge onto POMC neurons to regulate body weight. We probed the interaction of these pathways by generating transgenic mice overexpressing leptin (LepTg) without 5HT2c receptors. On a chow diet, the lean phenotype of LepTg mice was unaffected by the absence of… Expand
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