Deletion of the p85alpha regulatory subunit of phosphoinositide 3-kinase in cone photoreceptor cells results in cone photoreceptor degeneration.

@article{Ivanovic2011DeletionOT,
  title={Deletion of the p85alpha regulatory subunit of phosphoinositide 3-kinase in cone photoreceptor cells results in cone photoreceptor degeneration.},
  author={Ivana Ivanovic and Robert E. Anderson and Yun Zheng Le and Steven J. Fliesler and David M. Sherry and Raju V. S. Rajala},
  journal={Investigative ophthalmology & visual science},
  year={2011},
  volume={52 6},
  pages={3775-83}
}
PURPOSE Downregulation of the retinal insulin/mTOR pathway in mouse models of retinitis pigmentosa is linked to cone cell death, which can be delayed by systemic administration of insulin. A classic survival kinase linking extracellular trophic/growth factors with intracellular antiapoptotic pathways is phosphoinositide 3-kinase (PI3K), which the authors have shown to protect rod photoreceptors from stress-induced cell death. The role of PI3K in cones was studied by conditional deletion of its… CONTINUE READING