Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice.

@article{Geng2001DeletionOT,
  title={Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice.},
  author={Yan Geng and Qunyan Yu and Ewa T. Sicinska and Manjusri Das and Roderick Terry Bronson and Piotr Sicinski},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 1},
  pages={194-9}
}
D-type cyclins (cyclins D1, D2, and D3) are key components of cell cycle machinery in mammalian cells. These proteins are believed to drive cell cycle progression by associating with their kinase partners, cyclin-dependent kinases, and by directing phosphorylation of critical cellular substrates. In addition, D-cyclins play a kinase-independent role by sequestering cell cycle inhibitors p27(Kip1) and p21(Cip1). In the past, we and others generated cyclin D1-deficient mice and have shown that… CONTINUE READING

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