Deletion of the p16 and p15 genes in human bladder tumors.


BACKGROUND Two genes, p16 (also known as CDKN2, INK4A, or MTS1) and p15 (also described as INK4B or MTS2), are found in tandem at chromosome 9p21. These genes are designated as candidate tumor suppressor genes because they encode proteins that function as negative cell cycle regulators. (The encoded polypeptides inactivate specific cyclin-protein kinase… (More)


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@article{Orlow1995DeletionOT, title={Deletion of the p16 and p15 genes in human bladder tumors.}, author={Irene Orlow and Louis Lacombe and Gregory J. Hannon and M Serrano and Inmaculada Pellicer and Guido Dalbagni and Victor Reuter and Zuo Feng Zhang and David H. Beach and Carlos Cordon-Cardo}, journal={Journal of the National Cancer Institute}, year={1995}, volume={87 20}, pages={1524-9} }