Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis

@article{Cid2009DeletionOT,
  title={Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis},
  author={Rafael de Cid and Eva Riveira-Mu{\~n}oz and Patrick L.J.M. Zeeuwen and Jason Robarge and Wilson Liao and Emma N Dannhauser and Emiliano Giardina and Philip E Stuart and Rajan P. Nair and Cynthia A Helms and Ge{\`o}rgia Escaram{\'i}s and Ester Ballana and Gemma Martin-Ezquerra and Martin den Heijer and Marijke Kamsteeg and Irma Joosten and Evan E. Eichler and Conxi L{\'a}zaro and Ram{\'o}n Ma Pujol and Llu{\'i}s Armengol and Gonçalo R. Abecasis and James T. Elder and Giuseppe Novelli and John A L Armour and Pui-Yan Kwok and Anne M. Bowcock and Joost Schalkwijk and Xavier Estivill},
  journal={Nature Genetics},
  year={2009},
  volume={41},
  pages={211-215}
}
Psoriasis is a common inflammatory skin disease with a prevalence of 2–3% in individuals of European ancestry. In a genome-wide search for copy number variants (CNV) using a sample pooling approach, we have identified a deletion comprising LCE3B and LCE3C, members of the late cornified envelope (LCE) gene cluster. The absence of LCE3B and LCE3C (LCE3C_LCE3B-del) is significantly associated (P = 1.38E–08) with risk of psoriasis in 2,831 samples from Spain, The Netherlands, Italy and the United… Expand
Deletion of the late cornified envelope genes LCE3C and LCE3B is associated with psoriasis in a Chinese population.
TLDR
It is found that deletion of the two LCE genes was associated with psoriasis (odds ratio=1.917; 95% confidence interval =1.291-2.847, P=0.001), a conclusion that was similar to that of another independent Chinese cohort study. Expand
Deletion of late cornified envelope genes, LCE3C_LCE3B-del, is not associated with psoriatic arthritis in Tunisian patients
TLDR
The data suggest that the LCE deletion, previously identified in patients with psoriasis, is not of a major importance in the development of PsA in Tunisian patients supporting the current perception that different genetic risk factors contribute to skin and joint disease. Expand
Deletion of late cornified envelope genes, LCE3C_LCE3B-del, is not associated with psoriatic arthritis in Tunisian patients
TLDR
The data suggest that the LCE deletion, previously identified in patients with psori- asis, is not of a major importance in the development of PsA in Tunisian patients supporting the current perception that different genetic risk factors contribute to skin and joint disease. Expand
Deletion of the late cornified envelope genes, LCE3C and LCE3B, is associated with rheumatoid arthritis.
TLDR
An association between the LCE3C_LCE3B-del and RA has been identified and a pleiotropic effect of a common genetic risk factor for autoimmune diseases that is involved in both psoriasis and RA is verified. Expand
Mutation analysis of the LCE3B/LCE3C genes in Psoriasis
TLDR
It is suggested that homozygosity for a common LCE3C_LCE3B deletion contributes to the risk of developing chronic plaque type Ps without psoriatic arthritis. Expand
Deletion of Late Cornified Envelope 3B and 3C genes is not associated with atopic dermatitis.
TLDR
The data suggest that the potential roles of skin barrier defects in the pathogenesis of AD and psoriasis are based on distinct genetic causes. Expand
Association analysis of LCE3C–LCE3B deletion in Tunisian psoriatic population
TLDR
The findings indicate that the LCE3C_LCE3B-del might play a role in familial psoriasis in the Tunisian population. Expand
Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6.
TLDR
The study highlights the value of examining genetic risk factors in multiple populations to identify genetic interactions, and indicates the need of further studies to understand the interaction of the skin barrier and the immune system in susceptibility to psoriasis. Expand
Feasibility of establishing deletion of the late cornified envelope genes LCE3B and LCE3C as a susceptibility factor for psoriasis
TLDR
It is inferred that LCE3C_LCE3B deletion does not appear to be associated with the risk of psoriasis in the population of Kashmiri ethnic population of North India. Expand
Replication of LCE3C-LCE3B CNV as a risk factor for psoriasis and analysis of interaction with other genetic risk factors.
TLDR
This study confirms the recently published finding that the deletion of the two LCE genes is a susceptibility factor for PsV with dosage effect, while, because of power limitation, no final conclusion regarding interaction with other PsV risk factors can be made at this stage. Expand
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