Deletion of the insulin receptor in the proximal tubule promotes hyperglycemia.

@article{Tiwari2013DeletionOT,
  title={Deletion of the insulin receptor in the proximal tubule promotes hyperglycemia.},
  author={Swasti Tiwari and Ravi Shankar Singh and Lijun Li and Susanna Tsukerman and Madan Madhav Godbole and Gaurav Shankar Pandey and Carolyn M A Ecelbarger},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2013},
  volume={24 8},
  pages={
          1209-14
        }
}
Nearly all renal tubular epithelial cells express insulin receptor. The insulin receptor in the distal tubule appears to modulate BP, but the role of the insulin receptor in the proximal tubule is unknown. Here, we selectively knocked out the insulin receptor from the proximal tubules of mice. Western blotting confirmed a two- to three-fold reduction in renal cortical homogenate insulin receptor-β among knockout mice compared with wild-type littermates. Young knockout mice exhibited a mildly… CONTINUE READING

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CR: A muscle-specific insulin recep- tor knockout exhibits features of the meta- bolic syndrome of NIDDM without altering

JC Brüning, MD Michael, +5 authors Kahn
  • J Am Soc Nephrol 24: ccc–ccc,
  • 2013