Deletion of the hypothetical protein SCO2127 of Streptomyces coelicolor allowed identification of a new regulator of actinorhodin production

@article{TierrafraVctor2016DeletionOT,
  title={Deletion of the hypothetical protein SCO2127 of Streptomyces coelicolor allowed identification of a new regulator of actinorhodin production},
  author={H. Tierrafr{\'i}aV{\'i}ctor and Licona-Cassani Cuauhtemoc and Maldonado-Carmona Nidia and Romero-Rodr{\'i}guez Alba and Centeno-Leija Sara and Marcellin Esteban and Rodr{\'i}guez-Sanoja Romina and Beatriz Ruiz-Villaf{\'a}n and K. NielsenLars and S{\'a}nchez Sergio},
  journal={Applied Microbiology and Biotechnology},
  year={2016},
  volume={100},
  pages={9229-9237}
}
Although the specific function of SCO2127 remains elusive, it has been assumed that this hypothetical protein plays an important role in carbon catabolite regulation and therefore in antibiotic biosynthesis in Streptomyces coelicolor. To shed light on the functional relationship of SCO2127 to the biosynthesis of actinorhodin, a detailed analysis of the proteins differentially produced between the strain M145 and the Δsco2127 mutant of S. coelicolor was performed. The delayed morphological… CONTINUE READING