Deletion of the gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen results in a mild metabolic phenotype

@article{Wang2006DeletionOT,
  title={Deletion of the gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen results in a mild metabolic phenotype},
  author={Yongping Wang and Cyrus C Martin and James K. Oeser and Suparna Sarkar and Owen P. McGuinness and John C. Hutton and Richard M. O’Brien},
  journal={Diabetologia},
  year={2006},
  volume={50},
  pages={774-778}
}
Islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP, now known as glucose-6-phosphatase, catalytic, 2 [G6PC2]) has recently been identified as a major autoantigen in mouse and human type 1 diabetes. Strategies designed to suppress expression of the gene encoding G6PC2 might therefore be useful in delaying or preventing the onset of this disease. However, since the function of G6PC2 is unclear, the concern with such an approach is that a change in G6PC2 expression might… CONTINUE READING