Deletion of the gene encoding CD59a in mice increases disease severity in a murine model of rheumatoid arthritis.

@article{Williams2004DeletionOT,
  title={Deletion of the gene encoding CD59a in mice increases disease severity in a murine model of rheumatoid arthritis.},
  author={A S Williams and Masashi Mizuno and Peter J Richards and Dewi S Holt and Brian Paul Morgan},
  journal={Arthritis and rheumatism},
  year={2004},
  volume={50 9},
  pages={3035-44}
}
OBJECTIVE To investigate the roles of CD59a in the protection of joint tissue in the context of murine antigen-induced arthritis (AIA). METHODS AIA was triggered in CD59a-deficient (CD59a(-/-)) mice and in CD59a-sufficient (CD59a(+/+)) controls; the course and severity of disease were compared between groups. The effects on arthritis of restoring CD59 to the joint in CD59a(-/-) mice by use of a membrane-targeted recombinant CD59 were also explored. RESULTS Disease, as assessed clinically by… CONTINUE READING