Deletion of the epigenetic regulator GcnE in Aspergillus niger FGSC A1279 activates the production of multiple polyketide metabolites.

@article{Wang2018DeletionOT,
  title={Deletion of the epigenetic regulator GcnE in Aspergillus niger FGSC A1279 activates the production of multiple polyketide metabolites.},
  author={Bin Wang and X. Li and D. Yu and Xiaoyi Chen and Jioji N. Tabudravu and H. Deng and L. Pan},
  journal={Microbiological research},
  year={2018},
  volume={217},
  pages={
          101-107
        }
}
  • Bin Wang, X. Li, +4 authors L. Pan
  • Published 2018
  • Biology, Medicine
  • Microbiological research
  • Epigenetic modification is an important regulatory mechanism in the biosynthesis of secondary metabolites in Aspergillus species, which have been considered to be the treasure trove of new bioactive secondary metabolites. In this study, we reported that deletion of the epigenetic regulator gcnE, a histone acetyltransferase in the SAGA/ADA complex, resulted in the production of 12 polyketide secondary metabolites in A. niger FGSC A1279, which was previously not known to produce toxins or… CONTINUE READING
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