Deletion of the alpha7 nicotinic receptor subunit gene results in increased sensitivity to several behavioral effects produced by alcohol.

@article{Bowers2005DeletionOT,
  title={Deletion of the alpha7 nicotinic receptor subunit gene results in increased sensitivity to several behavioral effects produced by alcohol.},
  author={Barbara J. Bowers and Tristan D. McClure-Begley and Jason J Keller and Richard E Paylor and Allan C. Collins and Jeanne M. Wehner},
  journal={Alcoholism, clinical and experimental research},
  year={2005},
  volume={29 3},
  pages={295-302}
}
BACKGROUND The finding that most people with alcoholism are also heavy smokers prompted several research groups to evaluate the effects of ethanol on neuronal nicotinic acetylcholine receptor (nAChR) function. Data collected in vitro indicate that physiologically relevant concentrations of ethanol inhibit the functional activation of homomeric alpha7 nAChRs, which are one of the most abundant nAChR subtypes expressed in the mammalian brain. The studies outlined here used alpha7 gene knockout… CONTINUE READING