Deletion of the activated protein-1 transcription factor JunD induces oxidative stress and accelerates age-related endothelial dysfunction.

@article{Paneni2013DeletionOT,
  title={Deletion of the activated protein-1 transcription factor JunD induces oxidative stress and accelerates age-related endothelial dysfunction.},
  author={Francesco Paneni and Elena Osto and Sarah Costantino and Bogdan Mateescu and Sylvie Briand and Giuseppe Coppolino and Enrico Perna and Pavani S Mocharla and Alexander Akhmedov and Ruslan Kubant and Lucia Rohrer and Tadeusz Malinski and Giovanni G Camici and Christian M Matter and Fatima Mechta-Grigoriou and Massimo Volpe and Thomas Felix L{\"u}scher and Francesco Cosentino},
  journal={Circulation},
  year={2013},
  volume={127 11},
  pages={1229-40, e1-21}
}
BACKGROUND Reactive oxygen species are major determinants of vascular aging. JunD, a member of the activated protein-1 family of transcription factors, is emerging as a major gatekeeper against oxidative stress. However, its contribution to reactive oxygen species homeostasis in the vasculature remains unknown. METHODS AND RESULTS Endothelium-dependent vasorelaxation was impaired in young and old JunD(-/-) mice (6 and 22 months old) compared with age-matched wild-type mice. JunD(-/-) mice… CONTINUE READING
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