Deletion of the WNT target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis.

@article{Zeilstra2008DeletionOT,
  title={Deletion of the WNT target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis.},
  author={Jurrit Zeilstra and Sander P. J. Joosten and Maarten Dokter and Eug{\`e}ne T P Verwiel and Marcel Spaargaren and Steven T. Pals},
  journal={Cancer research},
  year={2008},
  volume={68 10},
  pages={3655-61}
}
Mutation of the genes encoding the WNT signaling components adenomatous polyposis coli or beta-catenin plays a critical role in the initiation of colorectal cancer. These mutations cause constitutively active beta-catenin/TCF-mediated transcription, driving the transformation of intestinal crypts to colorectal cancer precursor lesions, called dysplastic aberrant crypt foci. CD44 is a prominent WNT signaling target in the intestine and is selectively expressed on the renewing epithelial cells… CONTINUE READING

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Genomic structure of DNA encoding the Research

  • GR Screaton, MV Bell, DG Jackson, FB Cornelis, U Gerth, JI. Bell
  • on April
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