Deletion of the Ttf1 gene in differentiated neurons disrupts female reproduction without impairing basal ganglia function.

@article{Mastronardi2006DeletionOT,
  title={Deletion of the Ttf1 gene in differentiated neurons disrupts female reproduction without impairing basal ganglia function.},
  author={Claudio M Mastronardi and Gregory G Smiley and Jacob Raber and Takashi Kusakabe and Akio Kawaguchi and Val{\'e}rie Matagne and Anja Dietzel and Sabine Heger and Alison E Mungenast and Ricardo Cabrera and Shioko Kimura and Sergio R. Ojeda},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 51},
  pages={13167-79}
}
Thyroid transcription factor 1 (TTF1) [also known as Nkx2.1 (related to the NK-2 class of homeobox genes) and T/ebp (thyroid-specific enhancer-binding protein)], a homeodomain gene required for basal forebrain morphogenesis, remains expressed in the hypothalamus after birth, suggesting a role in neuroendocrine function. Here, we show an involvement of TTF1… CONTINUE READING