Deletion of the Transcription Factor PGC-1α in Mice Negatively Regulates Bone Mass

@article{Colaianni2018DeletionOT,
  title={Deletion of the Transcription Factor PGC-1α in Mice Negatively Regulates Bone Mass},
  author={Graziana Colaianni and Luciana Lippo and Lorenzo Sanesi and Giacomina Brunetti and Monica Celi and Nunzio Cirulli and Giovanni Passeri and Janne E Reseland and Ernestina Schipani and Maria Felicia Faienza and Umberto Tarantino and Silvia Colucci and Maria Grano},
  journal={Calcified Tissue International},
  year={2018},
  volume={103},
  pages={638-652}
}
Peroxisome proliferator-activated receptor-gamma coactivator (PGC1α) is a transcription coactivator that interacts with a broad range of transcription factors involved in several biological responses. Here, we show that PGC1α plays a role in skeletal homeostasis since aged PGC1α-deficient mice (PGC1α−/−) display impaired bone structure. Micro-CT of the tibial mid-shaft showed a marked decrease of cortical thickness in PGC1α−/− (− 11.9%, p < 0.05) mice compared to wild-type littermate… CONTINUE READING
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