Deletion of the TNFAIP3/A20 gene detected by FICTION analysis in classical Hodgkin lymphoma

Abstract

The TNFAIP3 gene, which encodes a ubiquitin-modifying enzyme (A20) involved in the negative regulation of NF-κB signaling, is frequently inactivated by gene deletions/mutations in a variety of B-cell malignancies. However, the detection of this in primary Hodgkin lymphoma (HL) specimens is hampered by the scarcity of Hodgkin Reed-Sternberg (HR-S) cells even… (More)
DOI: 10.1186/1471-2407-12-457

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