Deletion of the RNaseIII Enzyme Dicer in Thyroid Follicular Cells Causes Hypothyroidism with Signs of Neoplastic Alterations

@inproceedings{Rodriguez2012DeletionOT,
  title={Deletion of the RNaseIII Enzyme Dicer in Thyroid Follicular Cells Causes Hypothyroidism with Signs of Neoplastic Alterations},
  author={Wendy Rodriguez and Ling Jin and V{\'e}ronique Janssens and Christophe E Pierreux and Anne-Christine Hick and Eneko Urizar and Sabine Costagliola},
  booktitle={PloS one},
  year={2012}
}
Micro-RNAs (miRNAs) are small non-coding RNAs that regulate gene expression, mainly at mRNA post-transcriptional level. Functional maturation of most miRNAs requires processing of the primary transcript by Dicer, an RNaseIII-type enzyme. To date, the importance of miRNA function for normal organogenesis has been demonstrated in several mouse models of tissue-specific Dicer inactivation. However, the role of miRNAs in thyroid development has not yet been addressed. For the present study, we… CONTINUE READING
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