Deletion of the PER3 gene on chromosome 1p36 in recurrent ER-positive breast cancer.

  title={Deletion of the PER3 gene on chromosome 1p36 in recurrent ER-positive breast cancer.},
  author={Joan Climent and Jesus Perez-losada and David A. Quigley and Il-Jin Kim and Reyno Delrosario and Kuang-Yu Jen and A. A. I. v't Pad Bosch and A{\~n}a Lluch and J Mao and Allan Balmain},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={28 23},
PURPOSE To investigate the role of the PER3 circadian rhythm gene, located within the commonly deleted region of chromosome 1p36, in human breast cancer development. PATIENTS AND METHODS The frequency of genetic alterations at 1p36 and PER3 gene copy number status were analyzed in 180 lymph node-negative breast cancers from patients who had received treatment with chemotherapy and/or tamoxifen. The expression levels of PER3 were also analyzed using published microarray profiles from > 400… CONTINUE READING


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