Deletion of the Mycobacterium tuberculosis pknH gene confers a higher bacillary load during the chronic phase of infection in BALB/c mice.

@article{Papavinasasundaram2005DeletionOT,
  title={Deletion of the Mycobacterium tuberculosis pknH gene confers a higher bacillary load during the chronic phase of infection in BALB/c mice.},
  author={Kadamba Papavinasasundaram and Bosco H Y Chan and Ji-Hae Chung and M. Joseph Colston and Elaine O. Davis and Yossef Av-Gay},
  journal={Journal of bacteriology},
  year={2005},
  volume={187 16},
  pages={5751-60}
}
The role of the serine/threonine kinase PknH in the physiology and virulence of Mycobacterium tuberculosis was assessed by the construction of a pknH deletion mutant. Deletion of the pknH gene did not affect sensitivity to the antimycobacterial drug ethambutol, although it was previously thought to be involved in regulating expression of emb genes encoding arabinosyl transferases, the targets of ethambutol. Nevertheless, transcription analyses revealed that genes associated with mycobacterial… CONTINUE READING

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