Deletion of the Ink4-locus (the p16ink4a, p14ARF and p15ink4b genes) predicts relapse in children with ALL treated according to the Nordic protocols NOPHO-86 and NOPHO-92

@article{Moreno2002DeletionOT,
  title={Deletion of the Ink4-locus (the p16ink4a, p14ARF and p15ink4b genes) predicts relapse in children with ALL treated according to the Nordic protocols NOPHO-86 and NOPHO-92},
  author={T C Moreno and G{\"o}ran Gustafsson and Stanislaw Garwicz and Dan Grand{\'e}r and G Jonmundsson and B A Frost and Anne M-T M{\"a}kipernaa and Omid Rasool and E R Savolainen and Kjeld Schmiegelow and Stefan S{\"o}derh{\"a}ll and Kim Vettenranta and Finn Wesenberg and Stefan Einhorn and Mats Heyman},
  journal={Leukemia},
  year={2002},
  volume={16},
  pages={2037-2045}
}
Inactivation of the Ink4 gene locus locus on 9p comprising the tumour suppressor gene p16ink4a and its neighbours p14ARF and p15ink4b is common in childhood acute lymphoblastic leukaemia (ALL), but the prognostic significance is controversial. DNA from 230 patients was retrospectively analysed by Southern blotting, single strand conformation polymorphism (SSCP) and sequencing techniques. The results were correlated with clinical characteristics and outcome. One hundred and ninety-four fully… CONTINUE READING

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