Deletion of the Inducible 70-kDa Heat Shock Protein Genes in Mice Impairs Cardiac Contractile Function and Calcium Handling Associated With Hypertrophy

@article{Kim2006DeletionOT,
  title={Deletion of the Inducible 70-kDa Heat Shock Protein Genes in Mice Impairs Cardiac Contractile Function and Calcium Handling Associated With Hypertrophy},
  author={Yun-Kyung Kim and Jorge A Suarez and Ying Hu and Patrick M. McDonough and Christa Boer and David J. Dix and Wolfgang H. Dillmann},
  journal={Circulation},
  year={2006},
  volume={113},
  pages={2589-2597}
}
Background— Hspa1a and Hspa1b genes encode stress-inducible 70-kDa heat shock proteins (Hsp70) that protect cells from insults such as ischemia. Mice with null mutations of both genes (KO) were generated, and their cardiac phenotype was explored. Methods and Results— Heart rate and blood pressures were normal in the KO mice. Hearts from KO mice were more susceptible to both functional and cellular damage by ischemia/reperfusion. Cardiac hypertrophy developed in Hsp70-KO mice. Ca2+ transients in… Expand
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