Deletion of the H19 transcription unit reveals the existence of a putative imprinting control element.

@article{Ripoche1997DeletionOT,
  title={Deletion of the H19 transcription unit reveals the existence of a putative imprinting control element.},
  author={M A Ripoche and Chantal Kress and Françoise Poirier and Luisa Dandolo},
  journal={Genes & development},
  year={1997},
  volume={11 12},
  pages={1596-604}
}
The distal region of mouse chromosome 7 contains a cluster of imprinted genes that includes H19 and Igf2 (insulin-like growth factor 2). H19 is expressed as an untranslated RNA found at high levels in endodermal and mesodermal embryonic tissues. This gene is imprinted and exclusively expressed from the allele of maternal origin. The Igf2 gene shows a similar pattern of expression but is expressed from the paternal allele. We have generated a targeted deletion of the H19 transcription unit by… CONTINUE READING