Deletion of the AcMNPV core gene ac109 results in budded virions that are non-infectious.

@article{Fang2009DeletionOT,
  title={Deletion of the AcMNPV core gene ac109 results in budded virions that are non-infectious.},
  author={Minggang Fang and Yingchao Nie and David A Theilmann},
  journal={Virology},
  year={2009},
  volume={389 1-2},
  pages={
          66-74
        }
}
Autographa californica multiple nucleopolyhedrovirus (AcMNPV) ac109 is a core gene and its function in the virus life cycle is unknown. To determine its role in the baculovirus life cycle, we used the AcMNPV bacmid system to generate an ac109 deletion virus (vAc(109KO)). Fluorescence and light microscopy showed that transfection of vAc(109KO) results in a single-cell infection phenotype. Viral DNA replication is unaffected and the development of occlusion bodies in vAc(109KO)-transfected cells… CONTINUE READING

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