Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice

  title={Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice},
  author={H. L. Cha and Jung-Mi Choi and Huy-Hyen Oh and Narayan Bashyal and S. Kim and L. Birnbaumer and H. Suh-Kim},
  journal={Molecular Brain},
  • H. L. Cha, Jung-Mi Choi, +4 authors H. Suh-Kim
  • Published 2019
  • Biology, Medicine
  • Molecular Brain
  • Go is a member of the pertussis toxin-sensitive Gi/o family. Despite its abundance in the central nervous system, the precise role of Go remains largely unknown compared to other G proteins. In the present study, we explored the functions of Go in the developing cerebellar cortex by deleting its gene, Gnao. We performed a histological analysis with cerebellar sections of adult mice by cresyl violet- and immunostaining. Global deletion of Gnao induced cerebellar hypoplasia, reduced arborization… CONTINUE READING
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