Deletion of the α-Arrestin Protein Txnip in Mice Promotes Adiposity and Adipogenesis While Preserving Insulin Sensitivity

@inproceedings{Chutkow2010DeletionOT,
  title={Deletion of the α-Arrestin Protein Txnip in Mice Promotes Adiposity and Adipogenesis While Preserving Insulin Sensitivity},
  author={William A. Chutkow and Andreas L Birkenfeld and Jonathan D Brown and Hui-Young Lee and David W. Frederick and Jun Yoshioka and Parth Patwari and Romy Kursawe and Samuel W. Cushman and Jorge Plutzky and Gerald I Shulman and Varman T Samuel and Richard T Lee},
  booktitle={Diabetes},
  year={2010}
}
OBJECTIVE Thioredoxin interacting protein (Txnip), a regulator of cellular oxidative stress, is induced by hyperglycemia and inhibits glucose uptake into fat and muscle, suggesting a role for Txnip in type 2 diabetes pathogenesis. Here, we tested the hypothesis that Txnip-null (knockout) mice are protected from insulin resistance induced by a high-fat diet. RESEARCH DESIGN AND METHODS Txnip gene-deleted (knockout) mice and age-matched wild-type littermate control mice were maintained on a… CONTINUE READING

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