Deletion of repeats in the alpha C protein enhances the pathogenicity of group B streptococci in immune mice.

@article{Gravekamp1998DeletionOR,
  title={Deletion of repeats in the alpha C protein enhances the pathogenicity of group B streptococci in immune mice.},
  author={Claudia Gravekamp and Bernard Rosner and Lawrence C. Madoff},
  journal={Infection and immunity},
  year={1998},
  volume={66 9},
  pages={4347-54}
}
The alpha C protein is a protective surface-associated antigen of group B streptococci (GBS). The prototype alpha C protein of GBS (strain A909) contains nine identical tandem repeats, each comprising 82 amino acids, flanked by N- and C-terminal domains. Clinical isolates of GBS show variable numbers of repeats with a normal distribution and a median of 9 to 10 repeats. Here, we show that escape mutants of GBS expressing one-repeat alpha C protein were 100-fold more pathogenic than GBS… CONTINUE READING

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