Deletion of presynaptic adenosine A1 receptors impairs the recovery of synaptic transmission after hypoxia

@article{Arrigoni2005DeletionOP,
  title={Deletion of presynaptic adenosine A1 receptors impairs the recovery of synaptic transmission after hypoxia},
  author={Elda Arrigoni and Amy J Crocker and Clifford B. Saper and Robert W Greene and Thomas E Scammell},
  journal={Neuroscience},
  year={2005},
  volume={132},
  pages={575-580}
}
Adenosine protects neurons during hypoxia by inhibiting excitatory synaptic transmission and preventing NMDA receptor activation. Using an adeno-associated viral (AAV) vector containing Cre recombinase, we have focally deleted adenosine A(1) receptors in specific hippocampal regions of adult mice. Recently, we found that deletion of A(1) receptors in the CA1 area blocks the postsynaptic responses to adenosine in CA1 pyramidal neurons, and deletion of A(1) receptors in CA3 neurons abolishes the… CONTINUE READING

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