Deletion of p66Shc longevity gene protects against experimental diabetic glomerulopathy by preventing diabetes-induced oxidative stress.

@article{Menini2006DeletionOP,
  title={Deletion of p66Shc longevity gene protects against experimental diabetic glomerulopathy by preventing diabetes-induced oxidative stress.},
  author={Stefano Menini and Lorena Amadio and Giovanna Oddi and Carlo Ricci and Carlo Pesce and Francesco Pugliese and Marco Giorgio and Enrica Migliaccio and Pier Giuseppe Pelicci and Carla Iacobini and Giuseppe Pugliese},
  journal={Diabetes},
  year={2006},
  volume={55 6},
  pages={1642-50}
}
p66(Shc) regulates both steady-state and environmental stress-dependent reactive oxygen species (ROS) generation. Its deletion was shown to confer resistance to oxidative stress and protect mice from aging-associated vascular disease. This study was aimed at verifying the hypothesis that p66(Shc) deletion also protects from diabetic glomerulopathy by reducing oxidative stress. Streptozotocin-induced diabetic p66(Shc) knockout (KO) mice showed less marked changes in renal function and structure… CONTINUE READING
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