Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice.

@article{Thomas2006DeletionOP,
  title={Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice.},
  author={Manesh Thomas and Dan Gavrila and Michael L. McCormick and Francis J. Miller and Alan Daugherty and Lisa A. Cassis and Kevin C. Dellsperger and Neal L. Weintraub},
  journal={Circulation},
  year={2006},
  volume={114 5},
  pages={404-413}
}
BACKGROUND Angiotensin II (Ang II) contributes to vascular pathology in part by stimulating NADPH oxidase activity, leading to increased formation of superoxide (O2-). We reported that O2- levels, NADPH oxidase activity, and expression of the p47phox subunit of NADPH oxidase are increased in human abdominal aortic aneurysms (AAAs). Here, we tested the hypothesis that deletion of p47phox will attenuate oxidative stress and AAA formation in Ang II-infused apoE-/- mice. METHODS AND RESULTS Male… CONTINUE READING