Deletion of p37Ing1 in mice reveals a p53-independent role for Ing1 in the suppression of cell proliferation, apoptosis, and tumorigenesis.

@article{Coles2007DeletionOP,
  title={Deletion of p37Ing1 in mice reveals a p53-independent role for Ing1 in the suppression of cell proliferation, apoptosis, and tumorigenesis.},
  author={Andrew H. Coles and Huiling Liang and Zhiqing Zhu and Concetta G A Marfella and Joonsoo Kang and Anthony N. Imbalzano and Stephen N. Jones},
  journal={Cancer research},
  year={2007},
  volume={67 5},
  pages={2054-61}
}
ING proteins have been proposed to alter chromatin structure and gene transcription to regulate numerous aspects of cell physiology, including cell growth, senescence, stress response, apoptosis, and transformation. ING1, the founding member of the inhibitor of growth family, encodes p37(Ing1), a plant homeodomain (PHD) protein that interacts with the p53 tumor suppressor protein and seems to be a critical cofactor in p53-mediated regulation of cell growth and apoptosis. In this study, we have… CONTINUE READING

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