Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene.

@article{Stairs2011DeletionOP,
  title={Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene.},
  author={Douglas B. Stairs and Lauren J. Bayne and Ben Rhoades and Mar{\'i}a Elisa Vega and Todd J. Waldron and Jiri Kalabis and Andres J. P. Klein-Szanto and Ju-Seog Lee and Jonathan P. Katz and J Alan Diehl and Albert B. Reynolds and Robert H. Vonderheide and Anil K Rustgi},
  journal={Cancer cell},
  year={2011},
  volume={19 4},
  pages={470-83}
}
p120-catenin (p120ctn) interacts with E-cadherin, but to our knowledge, no formal proof that p120ctn functions as a bona fide tumor suppressor gene has emerged to date. We report herein that p120ctn loss leads to tumor development in mice. We have generated a conditional knockout model of p120ctn whereby mice develop preneoplastic and neoplastic lesions in the oral cavity, esophagus, and squamous forestomach. Tumor-derived cells secrete granulocyte macrophage colony-stimulating factor (GM-CSF… CONTINUE READING
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