Deletion of open reading frame UL26 from the human cytomegalovirus genome results in reduced viral growth, which involves impaired stability of viral particles.

@article{Lorz2006DeletionOO,
  title={Deletion of open reading frame UL26 from the human cytomegalovirus genome results in reduced viral growth, which involves impaired stability of viral particles.},
  author={Kerstin Lorz and Heike Hofmann and Anja Maria Berndt and Nina Tavalai and Regina Mueller and Ursula M. Schl{\"o}tzer-Schrehardt and Thomas Stamminger},
  journal={Journal of virology},
  year={2006},
  volume={80 11},
  pages={5423-34}
}
We previously showed that open reading frame (ORF) UL26 of human cytomegalovirus, a member of the US22 multigene family of betaherpesviruses, encodes a novel tegument protein, which is imported into cells in the course of viral infection. Moreover, we demonstrated that pUL26 contains a strong transcriptional activation domain and is capable of stimulating the major immediate-early (IE) enhancer-promoter. Since this suggested an important function of pUL26 during the initiation of the viral… CONTINUE READING

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