Deletion of neutral endopeptidase exacerbates intestinal inflammation induced by Clostridium difficile toxin A.

@article{Kirkwood2001DeletionON,
  title={Deletion of neutral endopeptidase exacerbates intestinal inflammation induced by Clostridium difficile toxin A.},
  author={Kimberly S. Kirkwood and Nigel W Bunnett and John Maa and I Castagliolo and Bo Liu and Norma Gerard and Jeff Zacks and Charalabos Pothoulakis and Eileen F. Grady},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2001},
  volume={281 2},
  pages={G544-51}
}
Toxin A (TxA) of Clostridium difficile induces acute inflammation of the intestine initiated by release of substance P (SP) and activation of the neurokinin-1 receptor. However, the mechanisms that terminate this response are unknown. We determined whether the SP-degrading enzyme neutral endopeptidase (NEP, EC 3.4.24.11) terminates TxA-induced enteritis. We used both genetic deletion and pharmacological inhibition of NEP to test this hypothesis. In wild-type mice, instillation of TxA (0.5-5… CONTINUE READING
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