Deletion of membrane-associated Asp23 leads to upregulation of cell wall stress genes in Staphylococcus aureus.

@article{Mller2014DeletionOM,
  title={Deletion of membrane-associated Asp23 leads to upregulation of cell wall stress genes in Staphylococcus aureus.},
  author={Marret M{\"u}ller and Swantje Reiss and Rabea Schlueter and Ulrike M{\"a}der and Anica Beyer and Wenke Rei{\ss} and Jon Marles-Wright and Richard J Lewis and Henrike Pf{\"o}rtner and Uwe V{\"o}lker and Katharina Riedel and Michael Hecker and Susanne Engelmann and Jan Pan{\'e}-Farr{\'e}},
  journal={Molecular microbiology},
  year={2014},
  volume={93 6},
  pages={
          1259-68
        }
}
With about 25 000 molecules per cell, Asp23 is one of the most abundant proteins in Staphylococcus aureus. Asp23 has been characterized as a protein that, following an alkaline shock, accumulates in the soluble protein fraction. Transcription of the asp23 gene is exclusively regulated by the alternative sigma factor σ(B) , which controls the response of the bacterium to environmental stress. Sequence analysis identified Asp23 as a member of the widely distributed Pfam DUF322 family, precluding… CONTINUE READING

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