Deletion of macrophage migration inhibitory factor gene induces down regulation of sex hormones and ultrastructural abnormalities in mouse testes.

Abstract

Macrophage migration inhibitory factor (MIF) is a multifunctional protein that acts as a pro-inflammatory cytokine, pituitary hormone, immunoregulator and mitogen. The MIF gene knockout (MIFKO) mouse has been used to study the MIF response in many tissues, such as with skin injury and spinal cord injury; however, there is little information about the MIFKO… (More)

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@article{Anahara2006DeletionOM, title={Deletion of macrophage migration inhibitory factor gene induces down regulation of sex hormones and ultrastructural abnormalities in mouse testes.}, author={Reiko Anahara and Yoshiro Toyama and Masao Koda and Seijiro Honma and Jun Nishihira and Kiyotaka Toshimori and Chisato Mori}, journal={Reproductive toxicology}, year={2006}, volume={21 2}, pages={167-70} }