Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus.

@article{MatasRico2008DeletionOL,
  title={Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus.},
  author={Elisa Matas-Rico and Beatriz E Garcia-Diaz and Pedro Llebrez-Zayas and Diana L{\'o}pez-Barroso and Luis J Sant{\'i}n and Carmen Pedraza and Anibal Smith-Fern{\'a}ndez and Pedro Fern{\'a}ndez-Ll{\'e}brez and Teresa T{\'e}llez and Maximino Redondo and Jerold Chun and Fernando Rodr{\'i}guez de Fonseca and Guillermo Estivill-Torr{\'u}s},
  journal={Molecular and cellular neurosciences},
  year={2008},
  volume={39 3},
  pages={342-55}
}
Neurogenesis persists in certain regions of the adult brain including the subgranular zone of the hippocampal dentate gyrus wherein its regulation is essential, particularly in relation to learning, stress and modulation of mood. Lysophosphatidic acid (LPA) is an extracellular signaling phospholipid with important neural regulatory properties mediated by specific G protein-coupled receptors, LPA(1-5). LPA(1) is highly expressed in the developing neurogenic ventricular zone wherein it is… CONTINUE READING

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