Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice.

@article{Zhou2004DeletionOL,
  title={Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice.},
  author={Zhongjun Zhou and Masayuki Doi and Jianming Wang and Renhai Cao and Baohua Liu and K. M. Chan and Jarkko Kortesmaa and Lydia Sorokin and Yihai Cao and K. Tryggvason},
  journal={Cancer research},
  year={2004},
  volume={64 12},
  pages={4059-63}
}
Laminin-8 (alpha 4 beta 1 gamma 1) is one of the major laminin isoforms expressed in vascular endothelial basement membranes. Here we show that deletion of laminin-8 in mice affects angiogenesis under pathological conditions. Murine tumor models used in laminin alpha 4-deficient mice results in hyperneovascularization and significant promotion of tumor growth and metastasis. The higher tumor growth rates in mutant mice correlate with decreased tumor cell apoptosis. Depletion of laminin alpha 4… CONTINUE READING

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