Deletion of hepatic carbohydrate response element binding protein (ChREBP) impairs glucose homeostasis and hepatic insulin sensitivity in mice

@inproceedings{Jois2017DeletionOH,
  title={Deletion of hepatic carbohydrate response element binding protein (ChREBP) impairs glucose homeostasis and hepatic insulin sensitivity in mice},
  author={Tara Jois and Weiyi Chen and Victor G Howard and Rebecca E Harvey and Kristina Youngs and Claudia M. Thalmann and Pradip Kumar Saha and Lawrence C B Chan and Michael Alexander Cowley and M W Sleeman},
  booktitle={Molecular metabolism},
  year={2017}
}
OBJECTIVE Carbohydrate response element binding protein (ChREBP) is a transcription factor that responds to glucose and activates genes involved in the glycolytic and lipogenic pathways. Recent studies have linked adipose ChREBP to insulin sensitivity in mice. However, while ChREBP is most highly expressed in the liver, the effect of hepatic ChREBP on insulin sensitivity remains unknown. To clarify the importance of hepatic ChREBP on glucose homeostasis, we have generated a knockout mouse model… CONTINUE READING

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Liver - speci fi c inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob / ob mice

P. J. Enriori, W. Chen, +3 authors S. M. Comstock
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